AXL Antibody

This gene codes for a protein that belongs to the tyrosine kinase subfamily of the Tyro3-Axl-Mer (TAM) receptor. The encoded protein has an extracellular domain that consists of two fibronectin type-III motifs after two immunoglobulin-like motifs at the N-terminal. By binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6), it transduces signals from the extracellular matrix into the cytoplasm. This gene may be implicated in a number of biological processes, such as anti-inflammatory, growth, migration, and aggregation in many cell types. This gene produces several transcript variants as a result of alternative splicing. 

Receptor tyrosine kinase that, through binding growth factor GAS6, transduces signals from the extracellular matrix into the cytoplasm, thereby controlling a variety of physiological processes such as cell survival, proliferation, migration, and differentiation. AXL undergoes autophosphorylation and dimerization upon ligand interaction at the cell surface. After ligand activation, AXL binds to PI3-kinase subunits PIK3R1, PIK3R2, and PIK3R3, as well as GRB2, PLCG1, LCK, and PTPN11, and causes tyrosine phosphorylation of these subunits. Additional potential downstream substrates for AXL include CBL, NCK2, SOCS1, and TNS2. AXL recruits GRB2 and phosphatidylinositol 3 kinase regulatory subunits, which activates AKT kinase downstream. Gonadotropin-releasing hormone neuron survival and migration, hepatic regeneration, optimal cytokine signaling during human natural killer cell development, platelet activation, and the regulation of thrombotic responses are just a few of the processes that GAS6/AXL signaling affects. 

For more: phospho AXL antibody

About Author